Embedded Files
2025
2025
Publication: Post-operative ileum transcriptomics implicate sex-biased mechanisms in Crohn’s disease recurrence
Publication: Post-operative ileum transcriptomics implicate sex-biased mechanisms in Crohn’s disease recurrence
This exciting study integrates genetics with gene expression regulation to uncover sex-specific differences in Crohn’s disease recurrence. Gene expression in 339 postoperative neoterminal ileum biopsies from Crohn’s disease patients were analyzed to understand why the disease often recurs after surgery. Genetic analyses revealed sex-specific effects and transcript changes related to lipid metabolism, membrane transport, and extracellular matrix processes. Overall, the findings highlight molecular mechanisms of postoperative recurrence that differ from those involved in initial disease development and point to new potential therapeutic targets beyond traditional cytokine-blocking treatments.
ibdgc face-to-face meeting 2025
ibdgc face-to-face meeting 2025
Oct 14, 2025
Last month, the IBDGC met for the annual IBDGC Face-to-Face Meeting at the Broad Institute, coinciding with ASHG 2025. The meeting consisted of presentations on progress, future goals, and great discussions, focusing around analyses and data projects. We even introduced a new segment to the meeting where we had analysts give flash presentations on current projects, with two top presenters selected by our External Advisory Board. Following the meeting, we gathered for dinner at Batifol Cambridge for some lovely French cuisine and drinks. Overall, the meeting was a great success! Big thanks to everyone who attended, and we also would like to thank the Broad Institute again for hosting and organizing this event. We look forward to the next time we get to meet face-to-face!
NIDDK IBDGC Annual face-to-face meeting hosted in boston, Massachusetts to coincide with ASHG
NIDDK IBDGC Annual face-to-face meeting hosted in boston, Massachusetts to coincide with ASHG
July 28, 2025
On October 14, 2025 the IBDGC will be convening for an annual face to face meeting. Taking advantage of the opportunity to attend one of the largest genetics conferences of the year, the IBDGC will utilize the first day of the conference as a springboard to evaluate aims and directions for the upcoming year. Representatives from all GRCs, the DCC, NIDDK and our newly created EAB will be attending this meeting.
We are looking forward to this event and the chance to see everyone in person!
Publication: ELEVEN GRAND CHALLENGES FOR INFLAMMATORY BOWEL DISEASE GENETICS and GENOMICS
Publication: ELEVEN GRAND CHALLENGES FOR INFLAMMATORY BOWEL DISEASE GENETICS and GENOMICS
January 6, 2025
Over the past two decades, significant progress has been made in understanding the genetic factors behind inflammatory bowel disease (IBD), laying the groundwork for genomic medicine. The NIDDK IBD Genetics Consortium identifies 11 key challenges for the next two decades, focusing on genetic architecture, cellular and molecular characterization, and personalized medicine applications. These challenges include investigating genetic variations across populations, refining causal variants, and developing precision therapeutics to address unmet medical needs.
2024
2024
2024 Sherman Prize awarded to IBDGC Collaborator - DERMOT MCGOVERN, MD/PhD
2024 Sherman Prize awarded to IBDGC Collaborator - DERMOT MCGOVERN, MD/PhD
September 25, 2024
Congratulations are in order for Dr. McGovern, who leads the McGovern Lab—also known as the Translational Genomics Group (TGG)—at Cedars Sinai. After two decades of tireless pursuit and collaboration with Dr. Targan and Dr. Janine Bilsborough, his dream of delivering personalized medicine is gaining momentum through their innovative anti-TL1A investigational therapy. Focused on identifying specific drug targets and biomarkers, Dr. McGovern and his team are dedicated to matching the right drug to the right patient, transforming the landscape of treatment and offering hope to those in need.
Learn more about the prestigious Sherman Prize: https://shermanprize.org/
Publication: Importance of Microbiome in Disease Recurrence
Publication: Importance of Microbiome in Disease Recurrence
July 4, 2024
Building on top of existing data available from the Ileal Resection cohort, the focus of this paper was tissue-associated microbiota. With 1,100+ samples obtained from three clinical time points, Cristian Hernenadez-Rocha, MD found distinct microbiome signatures that could predict future disease recurrence.
Mid-Year Meeting in Washington, DC
Mid-Year Meeting in Washington, DC
May 17, 2024
The IBDGC gathered in Washington, DC for a mid-year meeting to discuss ongoing progress in the working groups and to welcome newly awarded Ancillary R01 awardees into the consortium. Another major discussion point included leveraging clinical collaborators to increase recruitment to the Diversity in IBD study.
Thanks to those who participated and the EAB for your insights!
2023
2023
Publication: Clinical Predictors in Ileocolonic Resection Patients
Publication: Clinical Predictors in Ileocolonic Resection Patients
November 17, 2023
Cristian Hernandez-Rocha, MD along with Mark Lazarev, MD led the analysis using the Crohn's Disease Ileal Resection longitudinal study. Relying on data obtained from patients recruited to the study and their medical records, a multitude of clinical variables were assessed to determine which has the highest impact on disease recurrence. Several independent clinical predictors were identified as potentially important indicators that are not currently used in clinical practice.
Annual IBDGC Meeting
Annual IBDGC Meeting
November 3, 2023
On November 1st, the IBDGC held its annual in-person meeting in Washington, DC. The working group presentations led to very fruitful discussions that will undoubtedly help guide the future direction of the IBDGC's research and analysis in the coming months. High engagement from both trainees and senior investigators made for a synergistic meeting that marks one of the most successful in the IBDGC's history.
A special thanks to our EAB for the insightful input they provided!
2023 Sherman Prize awarded to IBDGC Collaborator - Thad Stappenbeck, MD/PhD
2023 Sherman Prize awarded to IBDGC Collaborator - Thad Stappenbeck, MD/PhD
September 16, 2023
A well-deserved congratulations is in order for Dr. Stappenbeck, the chair of Inflammation and Immunity at Cleveland Clinic and a long-time collaborator of the IBDGC. His research focuses on mechanisms of intestinal repair and the techniques he has developed have led to numerous advances in the field of IBD.
Learn more about the prestigious Sherman Prize: https://shermanprize.org/
NIDDK IBDGC Annual face-to-face meeting hosted in Washington, DC to coincide with ASHG
NIDDK IBDGC Annual face-to-face meeting hosted in Washington, DC to coincide with ASHG
August 29, 2023
On November 1, 2023 the IBDGC will be convening for an annual face to face meeting. Taking advantage of the opportunity to attend one of the largest genetics conferences of the year, the IBDGC will utilize the first day of the conference as a springboard to evaluate aims and directions for the upcoming year. Representatives from all GRCs, the DCC, NIDDK and our newly created EAB will be attending this meeting.
We are looking forward to this event and the chance to see everyone in person!
Ancillary R01 Grants to the NIDDK Inflammatory Bowel Disease Genetics Consortium
Ancillary R01 Grants to the NIDDK Inflammatory Bowel Disease Genetics Consortium
August 8, 2023
NIDDK will be funding up to seven R01 awards with funding beginning in December 2023 or July 2024. A letter of support from the IBDGC Steering Committee is required. Investigators must submit a request for collaboration to the IBDGC by September 08, 2023, for the November 08, 2023 due date.
Link to RFA.
For collaboration request, please reach out to dcc@ibdgc.org
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