Rutgers—Johns Hopkins

 IBD Genetics Research Center

Steve R. Brant, MD

Principal Investigator

Professor of Medicine and Chancellor Scholar

Chief, Division of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School

Adjunct Professor, Rutgers University Dept. of Genetics and Human Genetics Institute of New Jersey

Adjunct Professor, Gastroenterology and Hepatology, Dept. of Medicine, Johns Hopkins University School of Medicine

Data Manager and Director of Recruitment Coordinating Center

Satellite Recruitment Center Investigators

NIDDK IBDGC-related Goals

Specific Aims

Aim 1: Expand the African American (AA) IBD study population for gene mapping

Aim 2: Further identify disease variants for AA IBD by various methods including WGS for low frequency alleles, sex-specific analyses, admixture mapping, sex-based analyses, and novel association discovery by incorporating gene expression data and pathway analyses

Aim 3: examine gene expression in colonic epithelium from African Americans to identify differentially expressed genes and eQTLs relevant to ulcerative colitis in African Americ

Aim 4: determine if differences in open chromatin explains genetic loci with differential IBD genetic association by ethnic ancestry between whites, East Asians and AA’s.

Administrative Supplement

Evaluate pre-diagnostic sera for metabolites that are signatures of microbes that interact with Crohns disease (CD) innate immunity risk genes leading to development of CD

Major interests

Co-investigators